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September 1, 1989Journal of Biological ChemistryOpen Access

Pure Human Inactive Renin

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Population

Native human chorion laeve and culture medium of human chorion cells

Design

Preclinical

Authors

KHKoichi HigashimoriThe University of OsakaKMK MizunoImperial Household AgencySNShigeo NakajoYokohama University of Pharmacy

Discussion

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Implication

Confirms prorenin as native inactive renin in animal models; leaves open its role in human cardiovascular regulation.

Structured PICO

P
Population
Native human chorion laeve and culture medium of human chorion cells
I
Intervention
Purification of inactive renin using immunoaffinity chromatography and other steps
O
Outcome
Identity, molecular weight, specific activities, and amino acid sequence of inactive reninsurrogate

This basic science study demonstrates that native inactive renin is prorenin, formed after the removal of a 23-amino acid signal peptide from preprorenin.

Cite This Study

Higashimori et al. (1989) studied this question.

synapsesocial.com/papers/6a70f23b8031ec7bb1dcadd6https://doi.org/10.1016/s0021-9258(18)63748-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of pure human renal renin. Evidence for a subunit structure.1987 · 63 citations
  2. 2Human Chorionic Cells in Primary Culture: A Model for Renin Biosynthesis1982 · 99 citations
  3. 3Activation of Plasma and Amniotic Prorenin by Metalloprotease and Trypsin*1986 · 5 citations
  4. 4Biochemical and Immunological Characterization of Ectopic Tumoral Renin1982 · 25 citations
  5. 5Asynchronous changes in prorenin and renin secretion after captopril in patients with renal artery stenosis.1983 · 127 citations