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August 1, 1981Journal of Biological ChemistryOpen Access

Pure human renin. Identification and characterization and of two major molecular weight forms.

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Population

Human renal renin from normal kidney (10 kg)

Design

Preclinical

Authors

ESE E SlaterMerck & Co., Inc., Rahway, NJ, USA (United States)HSH.V. StroutMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

May explain renin assay variability in research; leaves open predominant form's physiological role and clinical translation.

Structured PICO

P
Population
Human renal renin from normal kidney (10 kg)
I
Intervention
Purification using sequential DEAE-cellulose chromatography, pepstatin affinity chromatography, gel filtration, and affinity chromatography
O
Outcome
Identification and characterization of molecular weight forms of pure human reninsurrogate

The study identifies two major molecular weight forms of human renin (50 kDa and 39 kDa), explaining the enzyme's instability and suggesting its true molecular size is larger than previously reported.

Cite This Study

Slater et al. (1981) studied this question.

synapsesocial.com/papers/6a7cd87ce9867978b6a1e26ehttps://doi.org/10.1016/s0021-9258(18)43403-5
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