Population
Mammalian cells transfected with a human preprorenin expression construct
Comparison
Expressed human prorenin vs Native human renal and plasma inactive renin
Design
Preclinical
Authors
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Supports prorenin as inactive renin; hypothesis-generating without immediate clinical implications.
Expressed human prorenin exhibits biochemical properties identical to native human inactive renin, supporting the hypothesis that human inactive renin is prorenin.
Hsueh et al. (1986) studied this question.
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