Why the study?
Does combined renal and cardiac injury induce additive damage to both organs in rat models of cardiorenal syndrome?
Population
Animal models of chronic kidney disease and heart failure, specifically rat models of combined CKD and HF
Comparison
Combined renal and cardiac injury vs Controls undergoing the same cardiac insult…
Design
Preclinical
Authors
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Additive cardiorenal damage occurs in rat models; extends crosstalk evidence but leaves human translation and therapy open.
Does combined renal and cardiac injury induce additive damage to both organs in rat models of cardiorenal syndrome?
Rat models of combined CKD and HF demonstrate that target organ cross talk occurs in cardiorenal syndrome, with additive damage to both organs.
Bongartz et al. (2012) studied this question.
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