COL5A1 rs13946 Polymorphism and Anterior Cruciate Ligament Injury: Systematic Review and Meta-Analysis

Figures

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  Figure 1. PRISMA flowchart showing the study-selection process.

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  Figure 2. Forest plot of the recessive model (TT versus TC + CC) of COL5A1 rs13946 for overall comparison. The blue points are the study’s OR. The blue horizontal line is 95% CI. References cited Lulińska-Kuklik et al., (2018) [18], Massidda et al., (2023), Posthumus et al., (2009) [13], Rodas et al., (2023) [19], Sivertsen et al., (2019) [26], Stepień-Słodkowska et al., (2015) [27], Zhao et al., (2020) [21]. RevMan 5.4 does not support the p-value in italics.

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  Figure 3. Forest plot of rs 13946 and ACL injury under the allele model (T versus C). The blue points are the study’s OR. The blue horizontal line is 95% CI. References cited Lulińska-Kuklik et al., (2018) [18], Massidda et al., (2023), Posthumus et al., (2009) [13], Rodas et al., (2023) [19], Sivertsen et al., (2019) [26], Stepień-Słodkowska et al., (2015) [27], Zhao et al., (2020) [21]. RevMan 5.4 does not support the p-value in italics.

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  Figure 4. Subgroup-analysis by ethnicity under the recessive model (TT versus TC + CC). The blue points are the study’s OR. The blue horizontal line is 95% CI. References cited Lulińska-Kuklik et al., (2018) [18], Massidda et al., (2023), Posthumus et al., (2009) [13], Stepień-Słodkowska et al., (2015) [27], Zhao et al., (2020) [21], Rodas et al., (2023) [19], Sivertsen et al., (2019) [26]. RevMan 5.4 does not support the p-value in italics.

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  Figure 5. Subgroup-analysis by gender under the recessive model (TT versus TC + CC). The blue points are the study’s OR. The blue horizontal line is 95% CI. References cited Lulińska-Kuklik et al., (2018) [18], Posthumus et al., (2009) [13], Stepień-Słodkowska et al., (2015) [27], Rodas et al., (2023) [19], Sivertsen et al., (2019) [26], Massidda et al., (2023), Zhao et al., (2020) [21]. RevMan 5.4 does not support the p-value in italics.

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  Figure 6. Funnel plot of the association between rs13946 and risk of ACL injury under the recessive model (TT versus TC + CC). The blue dots represent authors cited. The blue dashed lines indicate 95% CI. Vertical dashed line represents the pooled OR. References cited Lulińska-Kuklik et al., (2018) [18], Massidda et al., (2023), Posthumus et al., (2009) [13], Rodas et al., (2023) [19], Sivertsen et al., (2019) [26], Stepień-Słodkowska et al., (2015) [27], Zhao et al., (2020) [21].