Key result
COL1A1 GT genotype linked to ~120% higher musculoskeletal injury risk in active young adults.
Why the study?
The association between COL1A1 and COL5A1 gene variants and musculoskeletal injuries in physically active Caucasians is rarely described in the literature.
Do specific variants in the COL1A1 and COL5A1 genes increase the risk of musculoskeletal injuries in physically active Caucasian students?
Case-Control (n=114)
Yes
Do specific variants in the COL1A1 and COL5A1 genes increase the risk of musculoskeletal injuries in physically active Caucasian students?
Odds Ratio: 2.2 (95% CI 0.59–5.07)
p-value: p=0.040
The rs1800012 COL1A1 polymorphism, specifically the GT genotype, may be associated with a higher risk of physical activity-related musculoskeletal injuries in a Caucasian population.
COL1A1 rs1800012 GT genotype was associated with higher injury risk; leaves open validation in larger prospective cohorts before any clinical application.
The COL1A1 and COL5A1 variants have been associated with the risk of musculoskeletal injuries. Therefore, the main aim of the study was to investigate the association between three polymorphisms within two genes (rs1800012 in COL1A1, as well as rs12722 and rs13946 in COL5A1) and the reported, yet rarely described in the literature, injuries of the joint and muscle area in a physically active Caucasian population. Polish students (n = 114) were recruited and divided into the following two groups: students with (n = 53) and without (n = 61) injures. Genotyping was carried out using real-time PCR. The results obtained revealed a statistically significant association between rs1800012 COL1A1 and injury under an overdominant model. Specifically, when adjusted for age and sex, the GT heterozygotes had a 2.2 times higher chance of being injured compared with both homozygotes (TT and GG, 95% CI 0.59–5.07, p = 0.040). However, no significant interaction between the COL5A1 variants, either individually or in haplotype combination, and susceptibility to injury were found. In addition, the gene–gene interaction analysis did not reveal important relationships with the musculoskeletal injury status. It was demonstrated that rs1800012 COL1A1 may be positively associated with physical activity-related injuries in a Caucasian population. Harboring the specific GT genotype may be linked to a higher risk of being injured.
No takes yet. Share an insight, caveat, or question.
Leźnicka et al. (2021) conducted a case-control in Musculoskeletal injuries (n=114). rs1800012 COL1A1 GT genotype vs. rs1800012 COL1A1 TT and GG genotypes was evaluated on Musculoskeletal injuries (OR 2.2, 95% CI 0.59-5.07, p=0.040). The rs1800012 COL1A1 GT genotype was associated with a 2.2 times higher odds of musculoskeletal injuries compared to TT and GG homozygotes in physically active young adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: