June 1, 1986The Thoracic and Cardiovascular Surgeon
Myocardial Protection by Perioperative Diltiazem Drip: A Clinical Evaluation
Why the study?
Does perioperative diltiazem infusion improve myocardial preservation in CAD patients undergoing cardiac surgery?
Population
40 consecutive CAD patients undergoing cardiac surgery
Comparison
Diltiazem continuously infused at 0.5 to 2.0… vs Control group
Design
RCT, randomly assigned
Follow-up
48th postoperative hour
Authors
Discussion
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Member takes
Implication
Supports perioperative diltiazem for myocardial protection in CAD surgery; confirms RCT benefit on ischemic markers.
Structured PICO
Does perioperative diltiazem infusion improve myocardial preservation in CAD patients undergoing cardiac surgery?
P
Population
40 consecutive CAD patients undergoing cardiac surgery (involving cardiopulmonary bypass and aortic cross-clamping)
I
Intervention
Diltiazem continuously infused at 0.5 to 2.0 mcg/kg/min i.v. from anesthesia induction until aortic cross-clamping, and from myocardial reperfusion till the 48th postoperative hour
C
Comparator
Control group
O
Outcome
Myocardial preservation
Perioperative continuous infusion of diltiazem improves myocardial preservation and reduces ischemic events in CAD patients undergoing cardiac surgery.
Cite This Study
Donegani et al. (1986) studied this question.