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April 30, 2005International Journal of Angiology

Postoperative follow-up of coronary artery bypass patients receiving calcium antagonist diltiazem

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Why the study?

Does diltiazem reduce the incidence of arrhythmias and myocardial ischemia in elective coronary artery bypass patients?

Population

211 elective coronary artery bypass patients

Comparison

Diltiazem perioperatively as continuous 24-hour… vs Nitroglycerin perioperatively as continuous…

Design

RCT, randomized

Follow-up

2 years

Authors

MKMatthias KeilichUniversity of FreiburgCKChristiane KulinnaUniversity of FreiburgRSRainald SeitelbergerUniversity of Salzburg

Discussion

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Implication

Supports perioperative diltiazem in elective CABG; confirms benefit and extends evidence for arrhythmia and ischemia prevention.

Structured PICO

Does diltiazem reduce the incidence of arrhythmias and myocardial ischemia in elective coronary artery bypass patients?

P
Population
211 elective coronary artery bypass patients
I
Intervention
Diltiazem perioperatively as continuous 24-hour infusion (0.1 mg/kg/hour) followed by continuous oral medication postoperatively (3x50 mg/day)
C
Comparator
Nitroglycerin perioperatively as continuous 24-hour infusion (1 μg/kg/minute)
O
Outcome
Antiischemic and antiarrhythmic effects (including incidence of atrial fibrillation, ventricular arrhythmias, and ischemia-sensitive laboratory parameters)

Perioperative and postoperative diltiazem significantly reduces the incidence of arrhythmias and myocardial ischemia in patients undergoing elective coronary artery bypass surgery.

Cite This Study

Keilich et al. (2005) studied this question.

synapsesocial.com/papers/6a7ccfeee130ea38cea46294https://doi.org/10.1007/bf01616226
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diltiazem provides anti-ischemic and anti-arrhythmic protection in patients undergoing coronary bypass grafting1993 · 38 citations
  2. 2Antiarrhythmic actions of diltiazem during experimental atrioventricular reentrant tachycardias. Importance of use-dependent calcium channel-blocking properties.1990 · 25 citations
  3. 3Intravenous diltiazem for the treatment of supraventricular tachycardia1986 · 13 citations