Why the study?
Do genetic polymorphisms in SOD2, CAT, GSTT1, and GSTM1 increase the risk of late cardiac damage in childhood leukemia survivors treated with anthracyclines?
Population
76 long-term survivors of acute lymphoblastic leukemia in childhood exposed to anthracyclines
Comparison
Genetic polymorphisms in candidate genes… vs Patients without the specific genetic variants
Design
Cohort
Authors
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CAT rs10836235 CC homozygosity was associated with late cardiac damage; leaves open whether genotyping should guide surveillance in survivors.
Do genetic polymorphisms in SOD2, CAT, GSTT1, and GSTM1 increase the risk of late cardiac damage in childhood leukemia survivors treated with anthracyclines?
CC homozygosity for the CAT gene polymorphism rs10836235 is associated with an increased risk of late cardiac damage in childhood leukemia survivors treated with anthracyclines.
Rajić et al. (2009) studied this question.
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