Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma

Figures

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  Fig. 1. The p values of the follow-up and case-control studies of the ALL population. Results of the analysis including data of ALL patients are presented in this Figure. The p values are illustrated in a polar coordinate system, where the circular grids represent the negative logarithm of p values (axis on the left can be projected to grids). Intermittent line indicates border at p = 0.01 (− lg p = 2). Columns show the results of the follow-up analysis of FS, darker shades of blue mean stronger significance. The lowest p values were chosen from every follow-up category and from every model, if the number of cases was above 5. (The time of diagnosis was excluded.) Results of the case-control study are shown with red dots, sizes proportional with stronger significance. Most significant results of this plot were studied further on the total cohort including osteosarcoma patients as well

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  Fig. 2. Odds ratios for cardiotoxicity associated with the CYP3A5 rs4646450 genotype among subgroups of patients and also in the whole cohort. Results of the univariate logistic regression analysis performed on subpopulations of patients and also on the total cohort of patients. Subpopulations are determined based on the following factors: diagnosis, age at diagnosis, gender, risk group, chemotherapy protocol, cumulative ANT dose, recidive occurred. Black boxes represent OR, the number of cases is proportional with the width of the boxes. The lengths of the horizontal lines depict the 95% confidence intervals. Analysis of OR was not accomplished if the number of cases was 0. Abbreviations: ALL, acute lymphoblastic leukemia; OSC, osteosarcoma; no, number; yr., year; SR, standard-risk; IR, intermediate-risk; HR, high-risk

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  Fig. 3. Violin plot of fractional shortening in the total population. FS (%) by genotypes is shown in different follow-up categories. Light blue is the time of diagnosis, medium blue is the time of the anthracycline administration (acute phase), dark blue is the follow-up 5–10 years after therapy. FS is indicated in box plots, box is mean ± S.D., whiskers are means ±3 S.D. Violin plot describes the distribution of FS data, records out of mean ± 3SD are not shown. A: ABCC2 rs3740066; B: NQO1 rs1043470; C: SLC22A6 rs6591722