Why the study?
The effects of diazoxide and exercise on skeletal muscle contraction and oxidative stress during obesity had not been explored.
Does diazoxide and exercise improve muscle contraction and reduce oxidative stress in obese male Wistar rats?
Does diazoxide and exercise improve muscle contraction and reduce oxidative stress in obese male Wistar rats?
Diazoxide and exercise improve skeletal muscle function and reduce oxidative stress in a rat model of obesity.
Diazoxide with exercise may mitigate obese muscle dysfunction in animals; leaves open human translation.
Obesity causes insulin resistance and hyperinsulinemia which causes skeletal muscle dysfunction resulting in a decrease in contraction force and a reduced capacity to avoid fatigue, which overall, causes an increase in oxidative stress. KATP channel openers such as diazoxide and the implementation of exercise protocols have been reported to be actively involved in protecting skeletal muscle against metabolic stress; however, the effects of diazoxide and exercise on muscle contraction and oxidative stress during obesity have not been explored. This study aimed to determine the effect of diazoxide in the contraction of skeletal muscle of obese male Wistar rats (35 mg/kg), and with an exercise protocol (five weeks) and the combination from both. Results showed that the treatment with diazoxide and exercise improved muscular contraction, showing an increase in maximum tension and total tension due to decreased ROS and lipid peroxidation levels and improved glutathione redox state. Therefore, these results suggest that diazoxide and exercise improve muscle function during obesity, possibly through its effects as KATP channel openers.
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Gómez‐Barroso et al. (2020) studied this question.
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