Metal-free synthesis strategies towards amide bond formation: review

Amides are adaptable building blocks in synthetic organic chemistry that have a wide range of medicinal applications.They are also employed as industrial raw materials for the wide-ranging production of engineering plastics, detergents, and lubricants.A common reaction that continues to be one of the most significant transformations is the synthesis of amides.Amide bond forming reactions are critical for both polypeptide synthesis and medicinal chemistry.Most current approaches for amidation employ stoichiometric activating agents, but such methods are neither atom economical nor synthetically elegant.Catalytic approaches for amidation are potentially green and more ideal substitutes for current standard methods and thus are the subject of this review.Building the amide group is one of the more crucial changes in the creation of the synthetic plan and is crucial to the pharmaceutical sector.In order to emphasize the most recent developments in this "dateless" reaction, with a special focus on metal-free methodologies this review provides an overview of just relatively recent contributions that have been published in the previous few years.The present review offers an apt summary of amide bond formation with carboxylic acid substrates by taking advantage of several methods.We also show the reaction mechanisms of representative reactions in a detailed way with numerous examples and applications of these methods in the synthesis of bioactive compounds