Why the study?
Does Angiotensin II induce ERK activation and mitogenic signals via EGF-R transactivation in cardiac fibroblasts?
Population
Cardiac fibroblasts
Comparison
Angiotensin II stimulation, with or without… vs Unstimulated cells or cells without specific…
Design
Preclinical
Authors
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May implicate EGF-R in Ang II-mediated fibroblast proliferation; hypothesis-generating for remodeling mechanisms pending human validation.
Does Angiotensin II induce ERK activation and mitogenic signals via EGF-R transactivation in cardiac fibroblasts?
Angiotensin II induces mitogenic signals in cardiac fibroblasts via Ca2+/calmodulin-dependent transactivation of the epidermal growth factor receptor, highlighting a mechanism for cardiac remodeling.
Murasawa et al. (1998) studied this question.
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