Key result
Angiotensin II-induced ERK 1/2 activation in adult rat cardiac fibroblasts occurs via parallel signaling pathways controlled by intracellular calcium and PKCdelta, not via EGFR transactivation.
Population
Adult rat cardiac fibroblasts
Comparison
Angiotensin II with or without various inhibitors vs Control conditions or single inhibitors
Design
Preclinical
Authors
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Findings in rat fibroblasts remain preclinical; leaves open whether EGFR-independent ERK activation drives human cardiac fibrosis.
Angiotensin II activates ERK 1/2 in adult rat cardiac fibroblasts via parallel signaling pathways controlled by intracellular calcium and PKCdelta, rather than through epidermal growth factor receptor transactivation.
Olson et al. (2008) studied Cardiac fibrosis. Angiotensin II was evaluated on ERK 1/2 activation/phosphorylation. Angiotensin II-induced ERK 1/2 activation in adult rat cardiac fibroblasts occurs via parallel signaling pathways controlled by intracellular calcium and PKCdelta, not via EGFR transactivation.
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