Key result
Angiotensin II induces translocation and activation of protein kinase C in neonatal rat cardiac fibroblasts, but this activation does not critically mediate its mitogenic effects.
Population
Neonatal rat cardiac fibroblasts
Design
Preclinical
Authors
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Does not support PKC inhibition to curb Ang II-driven fibroblast proliferation; leaves open the primary mitogenic pathway in cardiac remodeling.
The mitogenic effects of angiotensin II on neonatal rat cardiac fibroblasts are not primarily mediated by protein kinase C activation.
Booz et al. (1995) studied this question. Angiotensin II was evaluated on Mitogenic effects and thymidine incorporation into DNA. Angiotensin II induces translocation and activation of protein kinase C in neonatal rat cardiac fibroblasts, but this activation does not critically mediate its mitogenic effects.
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