Why the study?
Perivascular adipose tissue attenuates its anti-contractile effect and aggravates endothelial dysfunction in obesity, prompting investigation into whether liraglutide could improve this vascular dysfunction by modulating PVAT-related signaling pathways.
Does liraglutide improve vascular dysfunction in high-fat diet-induced obese mice?
Population
C57BL/6 mice fed a normal-chow diet or a high-fat diet
Comparison
Liraglutide treatment vs no liraglutide treatment
Design
Animal and ex vivo laboratory study
Authors
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Liraglutide may restore PVAT function in obese mice; leaves open translation to human endothelial protection.
Does liraglutide improve vascular dysfunction in high-fat diet-induced obese mice?
Liraglutide improves vascular dysfunction in obesity by modulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue, providing a novel mechanism for its cardiovascular protective effects.
Han et al. (2019) studied this question.
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