Why the study?
Does fractional-dose intradermal IPV provide comparable immunogenicity to full-dose intramuscular IPV in infants?
Population
471 infants in Cuba, randomized at birth
Comparison
Fractional-dose inactivated poliovirus vaccine… vs Full doses of IPV given intramuscularly at 6…
Design
RCT, randomized at birth
Follow-up
30 days after completing the 3-dose schedule
Authors
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Full-dose intramuscular IPV remains necessary for adequate infant immunogenicity; challenges viability of fractional-dose intradermal schedules.
Does fractional-dose intradermal IPV provide comparable immunogenicity to full-dose intramuscular IPV in infants?
Fractional-dose IPV given intradermally at 6, 10, and 14 weeks results in suboptimal immunogenicity compared to full-dose intramuscular administration.
Resik et al. (2010) studied this question.
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