Why the study?
Does the choice of renin assay (DRC vs PRA) affect the rate of false-positive primary aldosteronism screening in women compared to men?
Population
40 normal individuals (19 ovulating women, 21 males of similar age)
Comparison
Measurement of aldosterone to renin ratio using… vs Single measurements in normal males of similar age
Design
Cross-sectional
Authors
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DRC-based ARR may increase luteal-phase false positives in women; leaves open whether PRA or sex-specific ranges improve screening accuracy.
Does the choice of renin assay (DRC vs PRA) affect the rate of false-positive primary aldosteronism screening in women compared to men?
Plasma renin activity is preferable to direct renin concentration for determining ARR in women to avoid false positives during the luteal phase, and sex-specific reference ranges may be required.
Ahmed et al. (2010) studied this question.
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