Why the study?
Does female sex and oral contraceptive use affect the diagnostic accuracy of ARR screening for primary aldosteronism?
Does female sex and oral contraceptive use affect the diagnostic accuracy of ARR screening for primary aldosteronism?
ARR screening for primary aldosteronism is significantly less accurate in women than in men, potentially due to the effects of oral contraceptives.
Sex may affect ARR accuracy; leaves open prospective validation of sex-specific thresholds before practice change.
ARR screening fails to predict positive ivSLT in most (60.2%) hypertensive women as compared with 14.8% of hypertensive men. ARR is more often increased in normotensive women than men. Oral contraceptive may affect ARR contributing to the diagnostic inaccuracy in women.
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Pizzolo et al. (2009) studied this question.