What question did this study set out to answer?

To assess the clinical performance of liquid-based cytology, human papillomavirus (HPV) testing, and visual inspection methods for cervical cancer screening and triage in women living with HIV.

August 2, 2021Cancer MedicineOpen Access

Performance of cervical cancer screening and triage strategies among women living with HIV in China

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Authors

RDRufei DuanKunming Institute of Zoology XZXuelian ZhaoChinese Academy of Medical Sciences & Peking Union Medical College HZHongyun ZhangCapital Medical University

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Implication

Cross-sectional study evaluates cervical screening and triage tests in women with HIV, demonstrating optimal accuracy with restricted HPV genotyping.

Key Points

To assess the clinical performance of liquid-based cytology, human papillomavirus (HPV) testing, and visual inspection methods for cervical cancer screening and triage in women living with HIV.
Recruited women living with HIV aged 18 and older from an HIV/AIDS clinic in Yunnan, China between 2019 and 2020.
Evaluated primary screening using physician- and self-collected HPV assays (HC2, cobas, Sansure), liquid-based cytology (LBC), and visual inspection with acetic acid or Lugol's iodine (VIA/VILI).
Assessed performance for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+), confirming suspected abnormalities with colposcopy and biopsy.
Physician-collected HPV tests showed high primary sensitivity (100% for HC2, 89.5% for cobas, 100% for Sansure) and specificities between 72.0% and 85.1%, with self-collected HPV sampling showing comparable diagnostic performance.
Primary LBC (ASCUS+) had 61.1% sensitivity and 96.3% specificity, whereas VIA/VILI exhibited 40.0% sensitivity and 77.3% specificity.
Restricted HPV genotyping triage (HPV-16/18/31/33/45/52/58) achieved optimal balance (89.5% sensitivity, 81.9% specificity), while antiretroviral therapy duration <2 years lowered specificity for HC2 (aOR: 1.87, 95% CI: 1.22–3.91) and Sansure (aOR: 2.48, 95% CI: 1.43–4.29).

Cite This Study

Duan et al. (2021) studied this question.

synapsesocial.com/papers/6a70d6b935aa2c282ce22a2d https://doi.org/10.1002/cam4.4152

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Implication

Cross-sectional study evaluates cervical screening and triage tests in women with HIV, demonstrating optimal accuracy with restricted HPV genotyping.

Performance of cervical cancer screening and triage strategies among women living with HIV in China

Discussion

Member takes

Implication

Key Points

Cite This Study

Performance of cervical cancer screening and triage strategies among women living with HIV in China

Discussion

Member takes

Implication

Key Points

Cite This Study

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