Why the study?
Does the timing of appropriate antibiotic therapy confound the efficacy of recombinant human activated protein C in patients with severe sepsis?
Population
Patients with severe sepsis and mice with gram-negative bacterial sepsis
Comparison
Recombinant human activated protein C / prompt… vs Placebo / delayed antibiotic therapy
Design
Editorial
Authors
Loading...
This letter highlights the critical importance of matching the timing of antibiotic administration between treatment and placebo groups in sepsis trials to avoid confounding mortality outcomes.
Does the timing of appropriate antibiotic therapy confound the efficacy of recombinant human activated protein C in patients with severe sepsis?
This letter highlights the critical importance of matching the timing of antibiotic administration between treatment and placebo groups in sepsis trials to avoid confounding mortality outcomes.
Grenade et al. (2001) studied this question.