Why the study?
Does early captopril treatment reduce plasma endothelin concentrations in patients with acute myocardial infarction?
Population
45 patients hospitalized for suspected anterior acute myocardial infarction within 4 h from the onset of…
Comparison
Captopril vs Placebo after thrombolysis
Design
RCT, randomized, double blind
Follow-up
72 hours
Authors
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Early captopril reduces endothelin in acute MI; confirms neurohormonal modulation in reperfused anterior infarction.
Does early captopril treatment reduce plasma endothelin concentrations in patients with acute myocardial infarction?
Early captopril administration significantly reduces plasma endothelin levels in the acute and subacute phases of reperfused anterior myocardial infarction.
Pasquale et al. (1997) studied this question.
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