Why the study?
Does captopril reduce thrombus formation and surface expression of platelet glycoprotein IIb/IIIa in patients with early postmyocardial infarction?
Population
25 patients with myocardial infarction (MI)
Comparison
Captopril administered for 12 days vs Control group
Design
RCT, double-blind
Follow-up
12 days
Authors
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Supports antithrombotic effects of captopril early post-MI; extends ACE inhibitor data to platelet function.
Does captopril reduce thrombus formation and surface expression of platelet glycoprotein IIb/IIIa in patients with early postmyocardial infarction?
Short-term captopril administration in early post-MI patients reduces platelet aggregation and glycoprotein IIb/IIIa expression, suggesting an antithrombotic mechanism that may contribute to its clinical benefits.
Zurbano et al. (1999) studied this question.
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