The observed discrepancy between platelet and plasma vWF multimeric patterns suggests that previously described repeating doublet or single band patterns represent minor subgroups of type IIC vWD.
Discrepant platelet-plasma vWF patterns in this case; hypothesis-generating for minor type IIC vWD subgroups and needs confirmation.
von Willebrand factor (vWF) from platelet lysate and plasma, collected in the presence of protease inhibitors, was studied in two patients with type IIC von Willebrand disease (vWD). Platelet and plasma vWF showed the smallest multimer increased, but the latter had a repeating single band whereas the former had a repeating "doublet." This platelet-plasma discrepancy observed for the first time in these patients suggests that the repeating "doublet" or single band described in other type IIC patients represent minor subgroups of type IIC vWD.
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Batlle et al. (1986) studied this question.
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