Why the study?
Does corin deficiency cause hypertension and impaired pro-ANP conversion in mice?
Does corin deficiency cause hypertension and impaired pro-ANP conversion in mice?
Corin is established as the physiological pro-ANP convertase, and its deficiency leads to spontaneous hypertension and cardiac hypertrophy in mice.
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Corin deficiency produces salt-sensitive hypertension and hypertrophy in mice; confirms its role as pro-ANP convertase but leaves human translation open.
Chan et al. (2005) studied this question.
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