An “Exercise” in Cardiac Metabolism
Population
Normal and hypertrophied hearts (general review)
Design
Review
Authors
Discussion
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Implication
Metabolic shifts in hypertrophied and lipid-overloaded hearts may guide future therapies; leaves open optimal substrate modulation strategies.
Structured PICO
P
Population
Normal and hypertrophied hearts (general review)
I
Intervention
Chronic exercise training
O
Outcome
Changes in cardiac metabolism and substrate utilization
Chronic exercise training may reverse the pathological metabolic shift seen in cardiac hypertrophy by enhancing fatty acid oxidation and normalizing glycolysis.
Limitations
- Challenges with exercise training studies relating to model, training modality, and metabolic parameter assessed
Cite This Study
Stephen C. Kolwicz (2018) studied this question.