Population
Rat ventricular RNA from multiple models of cardiac hypertrophy, n=46
Comparison
Microarray gene expression analysis vs Controls for each respective hypertrophy model
Design
Preclinical
Authors
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Supports shared hypertrophy pathways in rodent models; leaves open validation and therapeutic targeting in human disease.
A common gene program underlies hypertrophic remodeling across multiple rat models, suggesting a shared molecular basis for cardiac hypertrophy regardless of the induction method.
Strøm et al. (2004) studied this question.
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