Why the study?
Does pressure overload via transverse aortic constriction induce sex- and time-dependent genomic responses in the left ventricle of mice?
Population
Male and female mice (n=27 individual ventricles analyzed)
Design
Preclinical
Follow-up
1 day and 30 weeks
Authors
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Sex- and time-dependent LV gene regulation in murine overload reveals candidates for functional study; leaves open human HF translation.
Does pressure overload via transverse aortic constriction induce sex- and time-dependent genomic responses in the left ventricle of mice?
The acute and chronic genomic responses to pressure overload in the left ventricle are distinct and modified by sex, revealing novel genes for further functional analysis.
Weinberg et al. (2003) studied this question.
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