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January 24, 2017European Journal of Preventive CardiologyOpen Access

Looking beyond ectopic fat amount: A SMART method to quantify epicardial adipose tissue density

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Population

140 patients at high risk of cardiovascular disease from the SMART cohort substudy.

Design

Editorial

Authors

BGBénédicte GaboritADAnne Dutour

Discussion

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Overview

EAT density quantification may refine CV risk assessment in cohorts; leaves open incremental value over standard measures in prospective studies.

Structured PICO

P
Population
140 patients at high risk of cardiovascular disease (clinically manifest atherosclerotic vessel disease, or marked risk factors for atherosclerosis such as hypertension or type 2 diabetes) from the SMART cohort substudy.
I
Intervention
CT measured radiodensity of epicardial adipose tissue (EAT)
O
Outcome
Relationship between cardiovascular risk factors and CT measured radiodensity of EATsurrogate

Epicardial fat density measured by CT may serve as a sensitive, independent marker for evaluating cardiovascular risk beyond simple fat volume.

Limitations

  • No histological confirmation of the molecular and cellular characteristics of EAT
  • Mechanisms underlying EAT attenuation remain unknown

Cite This Study

Gaborit et al. (2017) studied this question.

synapsesocial.com/papers/6a70da616ceb2bbd16e004a8https://doi.org/10.1177/2047487317689976
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial adipose tissue: friendly companion or hazardous neighbour for adjacent coronary arteries?2008 · 41 citations
  2. 2Computed tomography measured epicardial adipose tissue and psoas muscle attenuation: new biomarkers to predict major adverse cardiac events (MACE) and mortality in patients with heart disease and critically ill patients. Part I: Epicardial adipose tissue2023 · 9 citations
  3. 3Original research. The Assessment of Epicardial Adipose Tissue in Acute Coronary Syndrome Patients. A Systematic Review2017 · 9 citations
  4. 4The Volume and Density of Epicardial Adipose Tissue Measured by Computed Tomography as Markers of the Effects of Cardiovascular Disease Risk Factors2026
  5. 5Epicardial adipose tissue and relationship with coronary artery disease2011 · 7 citations