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March 3, 2011Nephrology Dialysis TransplantationOpen Access

Elevated NT-proBNP and coronary calcium score in relation to coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion rate

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Why the study?

Does risk stratification with NT-proBNP and coronary calcium score identify significant coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion?

Population

200 asymptomatic type 2 diabetic patients without known CAD, with normal creatinine levels, and urinary…

Design

Cross-sectional

Authors

HRHenrik ReinhardPHPeter Riis HansenFPFrederik Persson

Discussion

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Overview

Over 50% of asymptomatic type 2 diabetic patients with elevated urinary albumin excretion and high NT-proBNP or CCS have significant CAD, highlighting the utility of this risk stratification approach.

Structured PICO

Does risk stratification with NT-proBNP and coronary calcium score identify significant coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion?

P
Population
200 asymptomatic type 2 diabetic patients without known CAD, with normal creatinine levels, and urinary albumin excretion rate (UAER) >30 mg/24 h.
I
Intervention
Risk stratification using P-NT-proBNP >45.2 ng/L and/or coronary calcium score (CCS) ≥ 400 to identify high-risk patients for further evaluation with myocardial perfusion imaging (MPI), CT angiography, and/or coronary angiography.
O
Outcome
Prevalence of significant coronary artery disease (CAD) demonstrated by MPI and/or coronary angiography.surrogate

Over 50% of asymptomatic type 2 diabetic patients with elevated urinary albumin excretion and high NT-proBNP or CCS have significant CAD, highlighting the utility of this risk stratification approach.

Cite This Study

Reinhard et al. (2011) studied this question.

synapsesocial.com/papers/6a70da616ceb2bbd16e004abhttps://doi.org/10.1093/ndt/gfr009
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Also Consider

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