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January 1, 2004Thrombosis and Haemostasis

Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation

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Why the study?

Does the p38 MAPK inhibitor VX-702 affect platelet aggregation in normal individuals?

Population

Platelets from normal individuals

Comparison

Pre-treatment with 1 microM VX-702 vs Absence of VX-702 / Aspirin

Design

Preclinical

Authors

AKAthan KuliopulosTufts University RMRamon MohanlalLigand Pharmaceuticals (United States)LCLidija CovicTufts University

Discussion

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Implication

May avoid bleeding risk unlike aspirin; hypothesis-generating for p38 MAPK inhibition in thrombosis.

Structured PICO

Does the p38 MAPK inhibitor VX-702 affect platelet aggregation in normal individuals?

P

Population

Platelets from normal individuals

I

Intervention

Pre-treatment with 1 microM VX-702 (a selective second generation p38 MAPK inhibitor)

C

Comparator

Absence of VX-702 / Aspirin

O

Outcome

Platelet aggregation induced by various agonists (thrombin, SFLLRN, AYPGKF, collagen, U46619, ristocetin)surrogate

Unlike aspirin, the p38 MAPK inhibitor VX-702 does not affect platelet aggregation, suggesting it would not increase bleeding risk in treated patients.

Cite This Study

Kuliopulos et al. (2004) studied this question.

synapsesocial.com/papers/6a70da62a528af2d65c3c78b https://doi.org/10.1160/th04-03-0187

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Adenosine diphosphate (ADP)–induced thromboxane A2generation in human platelets requires coordinated signaling through integrin αIIbβ3 and ADP receptors2002 · 172 citations
2Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue1996 · 295 citations
3Thrombin Induces Activation of p38 MAP Kinase in Human Platelets1995 · 217 citations
4Cloning and characterization of human protease-activated receptor 41998 · 825 citations
5Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ1997 · 490 citations