Key result
8-iso-PGF2alpha and low-dose U46619 induce platelet adhesion and shape change via a signaling pathway involving Syk, p38 MAP kinase, and actin polymerization.
Population
Washed platelets (in vitro model)
Design
Preclinical
Authors
Loading...
May identify new antiplatelet targets; leaves open translation to human thrombosis.
The signaling pathway for platelet adhesion and shape change induced by 8-iso-PGF2alpha and low-dose U46619 involves Syk, p38 MAP kinase, and actin polymerization.
Gaino et al. (2002) studied Platelet activation. 8-iso-PGF2alpha and U46619 was evaluated on Platelet shape change, adhesion, and p38 MAP kinase phosphorylation. 8-iso-PGF2alpha and low-dose U46619 induce platelet adhesion and shape change via a signaling pathway involving Syk, p38 MAP kinase, and actin polymerization.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: