Population
human platelets
Design
Preclinical
Authors
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p38 inhibition unlikely to curb platelet aggregation; leaves open whether targeting ADP/TxA2 pathways modulates thrombin signaling.
This study clarifies the upstream mediators of p38 MAP kinase activation by thrombin in human platelets, demonstrating mediation by ADP and TxA2 and inhibition by PKG, while showing p38 MAP kinase does not significantly contribute to platelet aggregation.
Begonja et al. (2006) studied this question.
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