January 1, 1998Thrombosis and Haemostasis

Inhibition of Fibrinogen Binding and Surface Recruitment of GpIIb/IIIa as Dose-Dependent Effects of the RGD-Mimetic MK-852

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Why the study?

Does MK-852 affect fibrinogen binding and GpIIb/IIIa surface expression in stimulated platelets?

Population

Whole blood platelets (in vitro model)

Design

Preclinical

Authors

KWK. WittigKlinik und Poliklinik für Kinder- und Jugendmedizin GRG. RotheLeiden University GSGerd SchmitzSemmelweis University

Discussion

Member takes

Implication

May require careful dosing to avoid unintended platelet effects; leaves open relevance to human thrombosis prevention.

Structured PICO

Does MK-852 affect fibrinogen binding and GpIIb/IIIa surface expression in stimulated platelets?

Population

Whole blood platelets (in vitro model)

Intervention

MK-852 (a cyclic hexapeptide based on the RGD-template)

Outcome

Surface binding of fibrinogen to ADP or TRAP-6 stimulated platelets and GpIIb/IIIa surface expressionsurrogate

MK-852 effectively inhibits fibrinogen binding at low concentrations but may cause paradoxical GpIIb/IIIa surface recruitment at higher doses.

Cite This Study

Wittig et al. (1998) studied this question.

synapsesocial.com/papers/6a70dbe735aa2c282ce230d3 https://doi.org/10.1055/s-0037-1614957

Topics

Dual antiplatelet therapy

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Inhibition of Fibrinogen Binding and Surface Recruitment of GpIIb/IIIa as Dose-Dependent Effects of the RGD-Mimetic MK-852

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inhibition of Fibrinogen Binding and Surface Recruitment of GpIIb/IIIa as Dose-Dependent Effects of the RGD-Mimetic MK-852

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider