Population
Platelets in whole blood and platelet-rich plasma incubated on extracellular matrix produced by bovine…
Comparison
Recombinant GPIb-binding fragment of von… vs Cell adhesion peptide RGDS or untreated control
Design
Preclinical
Authors
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Supports vWF-GPIb blockade to limit platelet adhesion; leaves open clinical translation for thrombosis prevention.
A recombinant GPIb-binding fragment of vWF (RG12986) effectively inhibits platelet aggregation on extracellular matrix, supporting the blockade of vWF-GPIb interaction to prevent thrombus formation.
Dardik et al. (1993) studied this question.
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