A novel, simple solid-phase binding assay using biotinylated fixed platelets and vWF-R497 mutant was established to screen for inhibitors of vWF-GPIb interaction, identifying D74-3736 as a potential antithrombotic agent.
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Establishes a screening assay for vWF-GPIb antagonists; leaves open whether identified compounds will prove clinically useful.
Hayata et al. (2008) studied this question.
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