Key result
In washed platelets, blocking the GPIIb-IIIa receptor decreased thrombin-induced shear aggregation by 95%, while blocking the vWF site on GPIb caused a 49% decrease.
GPIb serves a facilitative function in thrombin-induced platelet aggregation under shear stress by increasing contact time, allowing GPIIb-IIIa to yield stable attachment.
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Hypothesis-generating for receptor hierarchy in shear aggregation; leaves open translation to human thrombosis models.
Kasirer‐Friede et al. (1998) studied In vitro platelet aggregation. Ristocetin or thrombin activation was evaluated on Collision capture efficiency (alphaG). In washed platelets, blocking the GPIIb-IIIa receptor decreased thrombin-induced shear aggregation by 95%, while blocking the vWF site on GPIb caused a 49% decrease.
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