Clinical research on treatment of hypersplenism with microwave ablation

Objective To investigate the best method of the treatment for hypersplenism by ultrasound-guided microwave ablation.Methods 54 patients with the liver cirrhosis and portal hypertension disease were treated by color ultrasound-guided percutaneous latticed puncture microwave ablation,then white blood cell (WBC),red blood cell (RBC),platelet (PLT),and diameter (D),peak blood flow velocity (Vmax),mean blood flow velocity (Vmean) of splenic vein,splenic venous flows (Q) were detected before and after operation in the 7 th,30 th,90 th,180 th and 360 th day.Results Seven days after microwave ablation,both WBC and PLT were significantly higher than the levels before the operation (P ＜ 0.05),and Vmax,Vmean,Q of spenic arteriovenous were significantly higher than the levels before the operation (P ＜ 0.05),in addition,fiber cord could prevent compensatory hypertrophy of spleen after latticed microwave ablation.Conclusion Using percutaneous latticed puncture microwave ablation could treat the hypersplenism effectively,decrease portal pressure,improve low blood celluar caused by hypersplenism.And after combined with endoscopic variceal ligation it can prevent upper gastrointestinal bleeding.