Key result
NT-proBNP, E/Em, and LVMI were significantly higher in HFPEF patients compared to controls (P < 0.01), and NT-proBNP < 90 pg/ml had a 92.7% negative predictive value for diagnosing HFPEF.
Why the study?
Does NT-proBNP level correlate with echocardiographic parameters of diastolic function in patients with HFpEF?
Observational (n=109)
Does NT-proBNP level correlate with echocardiographic parameters of diastolic function in patients with HFpEF?
NT-proBNP levels correlate significantly with echocardiographic indices of diastolic dysfunction (E/Em) and offer a high negative predictive value for excluding HFpEF.
NT-proBNP <90 pg/ml may help exclude HFpEF; leaves open prospective validation of its diagnostic utility.
Objective To investigate the relationship between n-terminal pro-brain natriuretic peptide (NT-proBNP) level and echocardiographic parameter in patients with chronic heart failure with preserved ejection fraction (HFPEF) and evaluate the correlation,specificity and sensitivity on these indices.Methods Sixty-six symptomatic patients with isolated diastolic dysfunction and preserved left ventricular ejection fraction (LVEF) (≥ 50％) and forty-three people with normal left ventricular (LV) function were examined by conventional echocardiography,tissue Doppler imaging (TDI).Plasma NT-proBNP levels were determined simultaneously.Results Compared with control group,NT-proBNP,E/Em,LVMI were significantly higher in HFPEF (P ＜ 0.01); NT-proBNP was significantly correlated with E/Em (correlation coefficient r =0.576).Conclusion NT-proBNP,E/Em,LVMI were significant markers for reflecting left ventricular diastolic function and good tools for diagnosing HFPEF.NT-proBNP had a significant negative predictive value (92.7％) when NT-proBNP ＜ 90 pg/ml.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2014) conducted an observational in Chronic heart failure with preserved ejection fraction (HFPEF) (n=109). Chronic heart failure with preserved ejection fraction vs. Normal left ventricular function was evaluated on NT-proBNP, E/Em, and LVMI levels (r = 0.576, p=< 0.01). NT-proBNP, E/Em, and LVMI were significantly higher in HFPEF patients compared to controls (P < 0.01), and NT-proBNP < 90 pg/ml had a 92.7% negative predictive value for diagnosing HFPEF.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: