Key result
Higher NT-pro BNP levels were significantly associated with clinical suspicion of left ventricular diastolic dysfunction in hemodialysis patients with preserved ejection fraction (p=0.021).
Why the study?
Does NT-proBNP predict left ventricular diastolic dysfunction and HFpEF in hemodialysis patients without fluid overload?
Observational (n=83)
Does NT-proBNP predict left ventricular diastolic dysfunction and HFpEF in hemodialysis patients without fluid overload?
NT-proBNP may serve as a useful biomarker to screen for left ventricular diastolic dysfunction and HFpEF in hemodialysis patients, independent of fluid overload.
May support NT-proBNP screening for diastolic dysfunction in preserved-EF hemodialysis patients; leaves open prospective validation for HFpEF prediction.
BACKGROUND/AIMS: The diagnostic value of N-terminal pro-brain natriuretic peptide (NT-pro BNP) for heart failure with preserved ejection fraction (EF; HF-PEF) was evaluated in hemodialysis (HD) patients. METHOD: In total, 83 patients were analyzed. Left-ventricular (LV) function was assessed using trans-thoracic Doppler echocardiography, and indices of hydration status were assessed using bioelectrical impedance analysis. Plasma NT-pro BNP levels were measured simultaneously. RESULTS: A moderate negative correlation was found between NT-pro BNP and LVEF. Subsequently, 77 HD patients who maintained their LVEF (LVEF >50%) were analyzed. Patients with a clinical suspicion of LV diastolic dysfunction (LVDD; E/A ≤0.75) showed higher NT-pro BNP levels (p = 0.021), but no significant differences in hydration status were observed between the two groups. CONCLUSIONS: The NT-pro BNP level may be a very helpful biomarker in screening for LVDD and HF-PEF and determining the need for echocardiography or a sophisticated cardiac study, even in HD patients.
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Kamano et al. (2011) conducted an observational in Hemodialysis patients without fluid overload (n=83). NT-pro BNP was evaluated on NT-pro BNP levels in patients with clinical suspicion of LV diastolic dysfunction (E/A ≤0.75) (p=0.021). Higher NT-pro BNP levels were significantly associated with clinical suspicion of left ventricular diastolic dysfunction in hemodialysis patients with preserved ejection fraction (p=0.021).
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