Key result
A postdialysis serum NT-pro BNP cutoff value of 630 ng/L predicted left ventricular dysfunction in children with ESRD on hemodialysis with 86.6% sensitivity and 93.3% specificity (AUC 0.9).
Why the study?
Does serum NT-proBNP level accurately predict left ventricular dysfunction in children with end-stage renal disease on hemodialysis?
Population
30 children with end-stage renal disease (ESRD) on regular hemodialysis and 30 healthy controls
Comparison
Measurement of serum NT-proBNP levels before and… vs Healthy controls; and comparison between ESRD…
Design
Case-control
Authors
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May support NT-proBNP cutoff for LV dysfunction screening in pediatric HD; hypothesis-generating pending larger validation.
Case-Control (n=60)
Does serum NT-proBNP level accurately predict left ventricular dysfunction in children with end-stage renal disease on hemodialysis?
Effect estimate: AUC 0.9
p-value: p=<0.001
A postdialysis NT-proBNP cutoff of 630 ng/L serves as a highly sensitive and specific biomarker for detecting left ventricular dysfunction in children with ESRD on hemodialysis, independent of fluid overload.
Abdel-Hafez et al. (2016) conducted a case-control in End-stage renal disease (n=60). Serum NT-pro BNP levels vs. Healthy controls was evaluated on Left ventricular dysfunction (AUC 0.9, p=<0.001). A postdialysis serum NT-pro BNP cutoff value of 630 ng/L predicted left ventricular dysfunction in children with ESRD on hemodialysis with 86.6% sensitivity and 93.3% specificity (AUC 0.9).
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