What question did this study set out to answer?

To isolate and characterize a human inwardly rectifying potassium channel from the hippocampus.

June 21, 1994Proceedings of the National Academy of SciencesOpen Access

Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

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Authors

FPFrançois PérierUniversity of California, Santa Barbara CRCarolyn M. RadekeUniversity of California, Santa Barbara CVC A VandenbergKaleida Health

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Implication

Extends the molecular repertoire of human Kir channels with a low-conductance hippocampal isoform expressed in heart and muscle; leaves open its pathophysiological roles.

Key Points

To isolate and characterize a human inwardly rectifying potassium channel from the hippocampus.
Isolated cDNA encoding the channel termed HIR.
Conducted single-channel recordings to measure conductance.
Performed RNA blot analyses to detect HIR transcripts in various tissues.
The HIR channel displayed an unusually small conductance of 13 pS.
HIR transcripts were found in heart, skeletal muscle, and multiple brain regions including the hippocampus.

Cite This Study

Périer et al. (1994) studied this question.

synapsesocial.com/papers/6a70dd12e5469ee92be189f5 https://doi.org/10.1073/pnas.91.13.6240

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Implication

Extends the molecular repertoire of human Kir channels with a low-conductance hippocampal isoform expressed in heart and muscle; leaves open its pathophysiological roles.

Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

Discussion

Member takes

Implication

Key Points

Cite This Study

Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

Discussion

Member takes

Implication

Key Points

Cite This Study

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