Why the study?
Does Polygonatum cyrtonema polysaccharide prevent atherosclerosis in high-fat diet-induced LDLr−/− mice?
Does Polygonatum cyrtonema polysaccharide prevent atherosclerosis in high-fat diet-induced LDLr−/− mice?
PCP prevents HFD-induced atherosclerosis in LDLr−/− mice, with a more pronounced effect in males, potentially mediated by inhibiting NF-κB, MAPKs, and Akt signaling pathways.
Mouse data on PCP are hypothesis-generating; leaves open any clinical role in human atherosclerosis.
In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. NF-κB, MAPKs and Akt are three pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of IκB in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice is more obvious than that of female mice.
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Guo et al. (2023) studied this question.
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