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November 1, 2000The FASEB Journal

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle α‐actin null mouse

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Population

Smooth muscle (SM) alpha-actin null mice

Design

Preclinical

Authors

LSLisa A. SchildmeyerRBRenee M. BraunGTGeorge E. Taffet

Discussion

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Overview

SM alpha-actin null mice show impaired vascular function without developmental defects; extends preclinical actin biology but leaves open human relevance.

Structured PICO

P
Population
Smooth muscle (SM) alpha-actin null mice
I
Intervention
Genetic deletion of smooth muscle alpha-actin
O
Outcome
Vascular contractility, tone, blood flow, and cardiovascular system formationsurrogate

Smooth muscle alpha-actin is essential for regulating vascular contractility and blood pressure homeostasis, but not for the initial formation of the cardiovascular system.

Cite This Study

Schildmeyer et al. (2000) studied this question.

synapsesocial.com/papers/6a70decd31a3df8243291ea3https://doi.org/10.1096/fj.99-0927com
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ-actin1997 · 192 citations
  2. 2Analysis of SM22α-Deficient Mice Reveals Unanticipated Insights into Smooth Muscle Cell Differentiation and Function2001 · 170 citations
  3. 3Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin filament regulatory proteins2004 · 37 citations
  4. 4Mice Lacking Skeletal Muscle Actin Show Reduced Muscle Strength and Growth Deficits and Die during the Neonatal Period2002 · 115 citations
  5. 5Loss of smooth muscle α-actin effects on mechanosensing and cell–matrix adhesions2020 · 21 citations