October 1, 1996Anesthesia & Analgesia

Ketamine Blocks Currents Through Mammalian Nicotinic Acetylcholine Receptor Channels by Interaction with Both the Open and the Closed State

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Population

Mouse myotubes (nicotinic acetylcholine receptors)

Design

Preclinical

Authors

MSMichaela SchellerKlinikum rechts der Isar JBJohannes BuflerMunich University of Applied Sciences IHIris HertleKlinikum rechts der Isar

Discussion

Member takes

Implication

May indicate sub-clinical nAChR effects; hypothesis-generating for neuromuscular impact, requiring human validation.

Structured PICO

Population

Mouse myotubes (nicotinic acetylcholine receptors)

Intervention

Ketamine (increasing concentrations) applied with 10(-4) M acetylcholine (ACh) or preexposure to Ketamine before ACh activation

Outcome

Current amplitude and decay (open-channel block and closed-state interaction)surrogate

Ketamine interacts with both the open and closed states of the nicotinic acetylcholine receptor channel, causing block at concentrations below clinical levels.

Cite This Study

Scheller et al. (1996) studied this question.

synapsesocial.com/papers/6a70df0e31a3df8243291eee https://doi.org/10.1097/00000539-199610000-00031

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Ketamine Blocks Currents Through Mammalian Nicotinic Acetylcholine Receptor Channels by Interaction with Both the Open and the Closed State

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ketamine Blocks Currents Through Mammalian Nicotinic Acetylcholine Receptor Channels by Interaction with Both the Open and the Closed State

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider