Why the study?
Does ketamine alter ion currents and action potentials in human atrial myocytes?
Population
Human atrial myocytes isolated enzymatically from specimens of human atrial appendage obtained from patients…
Design
Preclinical
Authors
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May alter atrial APD at clinical doses; leaves open translation from animal models to human electrophysiology.
Does ketamine alter ion currents and action potentials in human atrial myocytes?
Ketamine at clinically relevant concentrations shortens the action potential duration of human atrial myocytes, likely by inhibiting L-type calcium currents.
Deng et al. (2008) studied this question.
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