Why the study?
Does ketamine affect myocardial contractility in rat cardiac papillary muscle?
Population
Rat left ventricular papillary muscle
Comparison
Ketamine at concentrations of 10 M and 10 M vs Baseline/control conditions at different…
Design
Preclinical
Authors
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Hypothesis-generating for ketamine's inotropic effects in low-calcium states; leaves open translation to human myocardium.
Does ketamine affect myocardial contractility in rat cardiac papillary muscle?
Ketamine exerts a positive inotropic effect on rat myocardium, likely via increased calcium influx, while impairing sarcoplasmic reticulum function at high concentrations.
Riou et al. (1989) studied this question.
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