Why the study?
The model currently used to extract tissue optical properties from SFR spectra was derived only for modified Henyey-Greenstein phase functions and is inadequate for other phase functions.
The proposed subdiffuse scattering and absorption model significantly improves the accuracy of extracting optical properties from single fiber reflectance spectroscopy across a wide range of tissue phase functions.
New SFR model extends phase function applicability; leaves open clinical validation for endoscopic use.
Single fiber reflectance (SFR) spectroscopy is a technique that is sensitive to small-scale changes in tissue. An additional benefit is that SFR measurements can be performed through endoscopes or biopsy needles. In SFR spectroscopy, a single fiber emits and collects light. Tissue optical properties can be extracted from SFR spectra and related to the disease state of tissue. However, the model currently used to extract optical properties was derived for tissues with modified Henyey-Greenstein phase functions only and is inadequate for other tissue phase functions. Here, we will present a model for SFR spectroscopy that provides accurate results for a large range of tissue phase functions, reduced scattering coefficients, and absorption coefficients. Our model predicts the reflectance with a median error of 5.6% compared to 19.3% for the currently used model. For two simulated tissue spectra, our model fit provides accurate results.
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Post et al. (2020) studied this question.
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