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July 1, 1977The Journal of Clinical Endocrinology & Metabolism

Plasma Renin and Angiotensin II Measurement in Hypertensive and Normal Subjects: Correlation of Basal and Stimulated States

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Why the study?

Do plasma renin activity and angiotensin II measurements correlate in peripheral venous blood across normal and hypertensive subjects?

Population

164 subjects including normal ambulant subjects, normal subjects after 7 days treatment with a thiazide…

Design

Cross-sectional

Authors

JSJ. D. SwalesGeneral / Preventive / LipidsHTH. ThurstonUniversity Hospitals of Leicester NHS Trust

Discussion

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Implication

Supports equivalence of PRA and AII in peripheral venous blood across groups; leaves open differential regulation during interventions or in renal veins.

Structured PICO

Do plasma renin activity and angiotensin II measurements correlate in peripheral venous blood across normal and hypertensive subjects?

P
Population
164 subjects including normal ambulant subjects (n=61), normal subjects after 7 days treatment with a thiazide diuretic (n=27), hypertensive subjects before and after a thiazide diuretic (n=35), severely hypertensive subjects after diazoxide treatment (n=14), and untreated severely hypertensive subjects (n=27).
I
Intervention
Measurement of Plasma renin activity (PRA) and angiotensin II (AII) in peripheral venous samples (and aortic/renal vein samples in a subset).
O
Outcome
Correlation between Plasma renin activity (PRA) and angiotensin II (AII) values.surrogate

Measurement of angiotensin II and plasma renin activity reflect changes in the renin-angiotensin system equally well in peripheral venous blood across various normal and hypertensive clinical states.

Cite This Study

Swales et al. (1977) studied this question.

synapsesocial.com/papers/6a70e13f2163a0a01bc51449https://doi.org/10.1210/jcem-45-1-159

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects11969 · 2,239 citations
  2. 2Effects of Oral Contraceptive Therapy on the Renin-Angiotensin System1971 · 86 citations
  3. 3Effect of Circulating Fragments of Angiotensin II on Radioimmunoassay in Arterial and Venous Blood1969 · 49 citations
  4. 4Blood Pressure in a National Sample of U. S. Adults: Percentile Distribution by Age, Sex and Race1973 · 35 citations
  5. 5Renin, Angiotensin II, and Adrenal Corticosteroid Relationships during Sodium Deprivation and Angiotensin Infusion in Normotensive and Hypertensive Man1972 · 54 citations