November 23, 2013AJP Heart and Circulatory PhysiologyOpen Access

Inducible cardiac arrhythmias caused by enhanced β1-adrenergic autoantibody expression in the rabbit

View Full Paper

Ask AI

Bookmark

Why the study?

Does enhanced β1-adrenergic autoantibody expression cause inducible cardiac arrhythmias in a rabbit model?

Population

8 young New Zealand white rabbits (3- to 4 months old)

Comparison

Immunization with 1 mg of β1-adrenergic receptor… vs Preimmune state subjected to the same…

Design

Preclinical

Follow-up

6 weeks

Authors

HLHongliang LiGuangzhou University of Chinese Medicine BSBenjamin J. ScherlagElectrophysiology DKDavid C. KemElectrophysiology

Discussion

Member takes

Implication

β1-autoantibodies increase inducible arrhythmias in rabbits; leaves open translation to human arrhythmia syndromes.

Structured PICO

Does enhanced β1-adrenergic autoantibody expression cause inducible cardiac arrhythmias in a rabbit model?

Population

8 young New Zealand white rabbits (3- to 4 months old)

Intervention

Immunization with 1 mg of β1-adrenergic receptor (β1AR) second extracellular loop (ECL2) peptide in complete/incomplete Freund's adjuvant at 0, 2, and 4 weeks, followed by catheter electrophysiological study with burst pacing and acetylcholine (ACh) infusion

Comparator

Preimmune state (each rabbit served as its own control) subjected to the same electrophysiological study with burst pacing and ACh infusion

Outcome

Occurrence of sustained (≥10 s) and nonsustained (<10 s) arrhythmias in response to burst pacing before and after ACh infusion (10 μM, 100 μM, and 1 mM)surrogate

Enhanced autoantibody activation of β1-adrenergic receptors in rabbits leads to tachyarrhythmias, predominantly sustained sinus tachycardia, providing a direct model for autoantibody-mediated arrhythmias.

Limitations

Anesthesia can have an effect on cardiac electrophysiology and arrhythmogenesis
Species-related differences in manifestations of tachyarrhythmias compared to humans

Cite This Study

Li et al. (2013) studied this question.

synapsesocial.com/papers/6a70e2ceb27f1581782790d9 https://doi.org/10.1152/ajpheart.00551.2013

View Full Paper

Ask AI

Bookmark

Inducible cardiac arrhythmias caused by enhanced β1-adrenergic autoantibody expression in the rabbit

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Inducible cardiac arrhythmias caused by enhanced β1-adrenergic autoantibody expression in the rabbit

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider